Data on other internal or external hard drives remains untouched. However, applications installed on those drives will likely need to be reinstalled because the new Windows registry won't have their entries.
Short answer: No — a clean install typically only formats or overwrites the drive/partition you choose, not every drive attached to the system. However, whether other drives are affected depends on the installer, your actions, and the operating system. Read the rest for specifics and safe procedures. does clean install wipe all drives exclusive
The keyword "exclusive" implies a specific set of circumstances where a clean install does wipe all drives. These are edge cases, but they happen frequently. Data on other internal or external hard drives
If you're nervous, physically disconnect your data drives before starting. However, whether other drives are affected depends on
Can I reinstall Windows 10 without losing my files? - Lenovo
Before starting, give your partitions clear names (e.g., "Games," "Backup") in File Explorer. During the installation screen, these labels help you identify which drive is which, as they may not appear as "C:" or "D:".