You may also try changing Fullscreen=ON to Fullscreen=OFF to force windowed mode, then switch back once the game launches.
support pages. Outdated audio codecs can also be updated via your motherboard manufacturer's site. Compatibility Mode: resident evil 6 fatal error failed open file
RE6 relies on older Visual C++ runtimes. Corruption here can manifest as file access errors. You may also try changing Fullscreen=ON to Fullscreen=OFF